Exercise training with blood flow restriction (BFR) is becoming increasingly popular in rehabilitation, allowing skeletal muscle strengthening and hypertrophy to be accomplished using lower workloads, fewer repetitions, and shorter durations. These benefits have been seen across a variety of musculoskeletal conditions and age ranges, however the predominant clinical focus has been on the younger orthopedic patient. Recently clinical application and research has begun to focus on the application of BFR for the geriatric sarcopenic patient, pediatrics and non-orthopedic diagnosis such as diabetes and Parkinson's disease. Additionally, angiogenic benefits and bone sparing mechanisms have increased research interest in the use of BFR to address vascular diseases and improve bone quality after surgery.

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